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Cell Tip

Analysis and understanding of fungal cell tip growth

Fungi cause devastating plant and human diseases. There is considerable evidence that much of the cellular machinery driving growth of invasive fungal hyphae is common across all fungi, including plant and mammalian pathogens, and involves localized tip growth.
We have developed and evaluated high-throughput automated microscope-based multi-dimensional image analysis systems to segment and characterize fungal growth, and characterize the patterns of protein localization within the tip that control development.

Local curvature-based approach for cell tip identification and tracking.

Local curvature-based approach for cell tip identification and tracking.

Collaborators:

  • Dr Mark Fricker, Department of Plant Sciences, University of Oxford, UK
  • Dr Alexander Lichius, Biotechnology and Microbiology Institute of Chemical Engineering, Vienna University of Technology, Austria
  • Prof. Nick Read, Institute of Inflammation and Repair, University of Manchester, UK

Publications:

  • [2014,article] bibtex
    A. Lichius, A. B. Goryachev, M. D. Fricker, B. Obara, E. Castro-Longoria, and N. D. Read, "CDC-42 and RAC-1 regulate opposite chemotropisms in Neurospora crassa," Journal of Cell Science, vol. 127, iss. 9, pp. 1953-1965, 2014.
    @article{Lichius2014,
      author = {Alexander Lichius and Andrew B. Goryachev and Mark D. Fricker and Boguslaw Obara and Ernestina Castro-Longoria and Nick D. Read},
      title = {{CDC-42} and {RAC-1} regulate opposite chemotropisms in {N}eurospora crassa},
      journal = {Journal of Cell Science},
      volume = {127},
      number = {9},
      pages = {1953-1965},
      year = {2014}
    }