Craig Manning personal page

Research interests

I currently work in the group of Prof. Stefan Przyborski building models of human skin.
I'm part of a project which is building an in silco model of signalling pathways involved in structure and function of skin. The model predictions are being validated against the biology. The model will be used to identify novel targets for application to skin health care. I'm also interested in:
  • Laboratory automation
  • Ageing
  • Bio-printing and fabrication
  • C. elegans imaging
My work profile is here: Durham profile
I have a blog I never update: Science & technology
And a few things I've built on Instructables

360o images and webVR

I'm learning A-frame to do web VR things, There's a few bits which almost work here: 360 and web vr

Health span assays

In 2017 I worked in the group of David Weinkove building tools to investigate nematode/bacterial interaction and assay health span.

Molarity calculator


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Healthy Ageing: From molecules to organisms

The meeting looked at both discoveries made in model organisms and mechanisms leading to healthy ageing in humans.
31st January - 2nd Feburary

Connectome to behaviour: modelling C. elegans at cellular resolution

This meeting brought together neuroscientists, physicists, and engineers to discuss advances in neural activity imaging, behaviour quantification, and multiscale simulations and how they are bringing the goal of whole-animal modelling at cellular resolution within reach.

Workshop 6-7th September 2017

The automated analysis of ageing in C. elegans and beyond!
6-7th Sept 2017

IUMS Congresses 2017

I attended the IUMS Congresses 2017 which was organised by the Singapore Society for Microbiology and Biotechnology (SSMB).

International worm meeting

International worm meeting Woo!

46th Annual Conference of the American Aging Association

Aging: Molecules to Main Street I attended the meeting an also won "Student achievement award" second place for my introdution to worm screen automation.

2017 Massachusetts life sciences innovation day

The first of my overseas ICURe meetings.

ICURe round 9

I was recently awarded funding from ICURe, an Innovation-to-Commercialisation programme, piloted by SETsquared and funded by HEFCE and Innovate UK. This funding will allow me to find out about how people outside my lab, both in academia and industry, use C.elegans and what questions they want to ask. With this information we will hopefuly be able to gauge how we could make our imaging rig an attractive solution.

Stock dilution

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Make this volume up to desired volume with your solvent (ml)

GENiE workshop

I presented some of our work on C. elegans automation at GENiE High content screening workshop 2017

Biosciences research away day 2017

My poster won a travel bursay price at the 2017 Biosciences research away day.

"Healthspan" machine

The study of C. elegans ageing uses lifespan as a biomarker. However, healthspan is shorter and arguably more relevant to human health. The heterogeneity of ageing means that studies require large numbers, particularly when interventions have small effects. To increase the rate and quality of information gathering we have built the Healthspan machine, an automated camera array that gathers information about changes in worm movement during aging. We use a single camera per plate and specific software to detect and quantify movement and its decline over a period of 7-10 days. We will present our progress and preliminary data. The aims of the rig are:
  • Compatibility with manual lifespan experiments.
  • Easily scalable from a single camera (>50 worms) to many hundreds of cameras.
  • Information about movement speed and distance over time.
  • Information about location over time (i.e. lawn avoidance).

The 66th BSRA Annual Scientific Meeting

I helped organise the 2016 BSRA meeting in durham.

BSI Pump priming: High throughput quantitative biology of ageing

The project aim was to replicate "The Lifespan Machine" designed by Walter Fontana’s group (Harvard). This system uses high resolution flatbed scanners that have been modified to image several plates of the nematode worm, C. elegans, twice an hour across several weeks (Stroustrup et al. Nature Methods 2013: 10, p665). This system has produced excellent data, however we started to shift interest toward using movement as a measurement for health.

3D Bioprinting meeting

I attended the "Opportunities and challenges" with 3D bioprinting meeting in October 2013 Cambridge

Oil red O script

The ImageJ analysis script from: Wojciechowicz et al 2013

Previous projects