Craig Manning personal page

Research interests

I work in the group of David Weinkove building tools to investigate nematode/bacterial interaction.
I'm also interested in:
  • C. elegans imaging
  • Laboratory automation
  • Ageing
  • Bio-printing and fabrication

Workshop 6-7th September 2017

The automated analysis of ageing in C. elegans and beyond!
6-7th Sept 2017

Molarity calculator

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IUMS Congresses 2017

I attended the IUMS Congresses 2017 which was organised by the Singapore Society for Microbiology and Biotechnology (SSMB).

International worm meeting

International worm meeting Woo!

46th Annual Conference of the American Aging Association

Aging: Molecules to Main Street I attended the meeting an also won "Student achievement award" second place for my introdution to worm screen automation.

2017 Massachusetts life sciences innovation day

The first of my overseas ICURe meetings.

ICURe round 9

I was recently awarded funding from ICURe, an Innovation-to-Commercialisation programme, piloted by SETsquared and funded by HEFCE and Innovate UK. This funding will allow me to find out about how people outside my lab, both in academia and industry, use C.elegans and what questions they want to ask. With this information we will hopefuly be able to gauge how we could make our imaging rig an attractive solution.

Stock dilution

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GENiE workshop

I presented some of our work on C. elegans automation at GENiE High content screening workshop 2017

Biosciences research away day 2017

My poster won a travel bursay price at the 2017 Biosciences research away day.

"Healthspan" machine

The study of C. elegans ageing uses lifespan as a biomarker. However, healthspan is shorter and arguably more relevant to human health. The heterogeneity of ageing means that studies require large numbers, particularly when interventions have small effects. To increase the rate and quality of information gathering we have built the Healthspan machine, an automated camera array that gathers information about changes in worm movement during aging. We use a single camera per plate and specific software to detect and quantify movement and its decline over a period of 7-10 days. We will present our progress and preliminary data. The aims of the rig are:
  • Compatibility with manual lifespan experiments.
  • Cost effective ~£100 per camera (>50 worms).
  • Easily scalable from a single camera (>50 worms) to many hundreds of cameras.
  • Information about movement speed and distance over time.
  • Information about location over time (i.e. lawn avoidance).

The 66th BSRA Annual Scientific Meeting

I helped organise the 2016 BSRA meeting in durham.

BSI Pump priming: High throughput quantitative biology of ageing

The project aim was to replicate "The Lifespan Machine" designed by Walter Fontana’s group (Harvard). This system uses high resolution flatbed scanners that have been modified to image several plates of the nematode worm, C. elegans, twice an hour across several weeks (Stroustrup et al. Nature Methods 2013: 10, p665). This system has produced excellent data, however we started to shift interest toward using movement as a measurement for health. By reproducing the system we were able to see the current state of the art and the power of this tool to address current questions. The insight gained has become a springboard to a Biology:Physics collaboration to facilitate a high throughput quantitative biology of ageing project using of-the-shelf- imaging technology. We hope our imaging rig will facilitate the gathering usefully large datasets and will be of value to the rest of the community.

3D Bioprinting meeting

I attended the "Opprtunities and challenges" with 3D bioprinting meeting in October 2013 Cambridge

Oil red O script

The ImageJ analysis script from: Wojciechowicz et al 2013

Previous projects